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KMID : 0388220070140020154
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Journal of the Korean Rheumatism Association
2007 Volume.14 No. 2 p.154 ~ p.159
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Two Cases of Adult Onset Still’s Disease with Disseminated Intravascular Coagulation and Multiple Organ Involvement Treated with Cyclosporine
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Shim Eun-Jin
Lee Ji-Soo
Lee You-Hyun
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Abstract
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Adult onset Still’s disease (AOSD) is a systemic inflammatory disorder of unknown etiology and pathogenesis. It is characterized by spiking fever, evanescent skin rash, arthralgia or arthritis, hepatosplenomegaly and laboratory abnormalities including neutrophilic leukocytosis, abnormal liver function tests and raised levels of serum ferritin. Coagulation abnormality is a rare presenting feature but it might be life threatening when associated with hepatopathy and hematologic abnormalities. We report two cases of AOSD with disseminated intravascular coagulation and multiple organ involvement, which improved with glucocorticoid and cyclosporine combination therapy
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KEYWORD
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Adult onset Still’s disease, Multiple organ failure, Disseminated intravascular coagulation, Cyclosporine
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